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Lowering Glycosphingolipid Levels in CD4(+) T Cells Attenuates T Cell Receptor Signaling, Cytokine Production, and Differentiation to the Th(17) Lineage
Lipid rafts reportedly have a role in coalescing key signaling molecules into the immunological synapse during T cell activation, thereby modulating T cell receptor (TCR) signaling activity. Recent findings suggest that a correlation may exist between increased levels of glycosphingolipids (GSLs) in...
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Main Authors: | , , , , , , , , , , , , , |
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Formáid: | Artigo |
Teanga: | Inglês |
Foilsithe: |
American Society for Biochemistry and Molecular Biology
2011
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Ábhair: | |
Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083190/ https://ncbi.nlm.nih.gov/pubmed/21402703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.218610 |
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