Ligation of Cytotoxic T Lymphocyte Antigen-4 to T Cell Receptor Inhibits T Cell Activation and Directs Differentiation into Foxp3(+) Regulatory T Cells

Cross-linking of ligand-engaged cytotoxic T lymphocyte antigen-4 (CTLA-4) to the T cell receptor (TCR) during the early phase of T cell activation attenuates TCR signaling, leading to T cell inhibition. To promote this event, a bispecific fusion protein comprising a mutant mouse CD80 (CD80w88a) and...

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Main Authors: Karman, Jozsef, Jiang, Ji-Lei, Gumlaw, Nathan, Zhao, Hongmei, Campos-Rivera, Juanita, Sancho, Jose, Zhang, Jinhua, Jiang, Canwen, Cheng, Seng H., Zhu, Yunxiang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322849/
https://ncbi.nlm.nih.gov/pubmed/22337882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.283705
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