Celastrus-derived Celastrol Suppresses Autoimmune Arthritis by Modulating Antigen-induced Cellular and Humoral Effector Responses

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and articular damage. Proinflammatory cytokines, antibodies, and matrix-degrading enzymes orchestrate the pathogenic events in autoimmune arthritis. Accordingly, these mediators of inflammation are the targets...

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Bibliografiske detaljer
Main Authors: Venkatesha, Shivaprasad H., Yu, Hua, Rajaiah, Rajesh, Tong, Li, Moudgil, Kamal D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083183/
https://ncbi.nlm.nih.gov/pubmed/21402700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226365
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