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Association of Botulinum Neurotoxin Serotype A Light Chain with Plasma Membrane-bound SNAP-25
The Clostridium botulinum neurotoxins (BoNTs) cleave SNARE proteins, which inhibit binding and thus fusion of neurotransmitter vesicles to the plasma membrane of peripheral neurons. BoNTs comprise an N-terminal light chain (LC) and C-terminal heavy chain, which are linked by a disulfide bond. There...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083167/ https://ncbi.nlm.nih.gov/pubmed/21378164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.224493 |
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