Amyloid-β42 Interacts Mainly with Insoluble Prion Protein in the Alzheimer Brain

The prion protein (PrP) is best known for its association with prion diseases. However, a controversial new role for PrP in Alzheimer disease (AD) has recently emerged. In vitro studies and mouse models of AD suggest that PrP may be involved in AD pathogenesis through a highly specific interaction w...

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Main Authors: Zou, Wen-Quan, Xiao, Xiangzhu, Yuan, Jue, Puoti, Gianfranco, Fujioka, Hisashi, Wang, Xinglong, Richardson, Sandy, Zhou, Xiaochen, Zou, Roger, Li, Shihao, Zhu, Xiongwei, McGeer, Patrick L., McGeehan, John, Kneale, Geoff, Rincon-Limas, Diego E., Fernandez-Funez, Pedro, Lee, Hyoung-gon, Smith, Mark A., Petersen, Robert B., Guo, Jian-Ping
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Neurobiology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083157/
https://ncbi.nlm.nih.gov/pubmed/21393248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.199356
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