Structure-Activity Relationship of Capsaicin Analogs and Transient Receptor Potential Vanilloid 1-Mediated Human Lung Epithelial Cell Toxicity

Activation of intracellular transient receptor potential vanilloid-1 (TRPV1) in human lung cells causes endoplasmic reticulum (ER) stress, increased expression of proapoptotic GADD153 (growth arrest- and DNA damage-inducible transcript 3), and cytotoxicity. However, in cells with low TRPV1 expressio...

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Autori principali: Thomas, Karen C., Ethirajan, Manivannan, Shahrokh, Kiumars, Sun, Hao, Lee, Jeewoo, Cheatham, Thomas E., Yost, Garold S., Reilly, Christopher A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2011
Soggetti:
Toxicology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083109/
https://ncbi.nlm.nih.gov/pubmed/21343315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.178491
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