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Conformational dynamics of CYP3A4 demonstrate the important role of Arg212 coupled with the opening of ingress, egress and solvent channels to dehydrogenation of 4-hydroxy-tamoxifen
BACKGROUND: Structure-based methods for P450 substrates are commonly used during drug development to identify sites of metabolism. However, docking studies using available x-ray structures for the major drug-metabolizing P450, CYP3A4, do not always identify binding modes supportive of the production...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3404218/ https://ncbi.nlm.nih.gov/pubmed/22677141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2012.05.011 |
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