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In vivo generation of highly abundant sequence-specific oligonucleotides for antisense and triplex gene regulation.

Antisense and triplex oligonucleotides continue to demonstrate potential as mediators of gene-specific repression of protein synthesis. However, inefficient and heterogeneous cellular uptake, intracellular sequestration, and rapid intracellular and extracellular degradation represent obstacles to th...

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Hlavní autoři: Noonberg, S B, Scott, G K, Garovoy, M R, Benz, C C, Hunt, C A
Médium: Artigo
Jazyk:Inglês
Vydáno: 1994
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC308254/
https://ncbi.nlm.nih.gov/pubmed/8052538
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