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Crystal Structure of the HIV-2 Neutralizing Fab Fragment 7C8 with High Specificity to the V3 Region of gp125

7C8 is a mouse monoclonal antibody specific for the third hypervariable region (V3) of the human immunodeficiency virus type 2 (HIV-2)-associated protein gp125. The three-dimensional crystal structure of the Fab fragment of 7C8, determined to 2.7 Å resolution, reveals a deep and narrow antigen-bindi...

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Autors principals: Uchtenhagen, Hannes, Friemann, Rosmarie, Raszewski, Grzegorz, Spetz, Anna-Lena, Nilsson, Lennart, Achour, Adnane
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082531/
https://ncbi.nlm.nih.gov/pubmed/21541316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018767
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