Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding

The tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine playing a key role in tissue regeneration and remodeling. Dysregulation of TWEAK signaling is involved in various pathological processes like autoimmune diseases and cancer. The unique interaction with its...

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Dades bibliogràfiques
Autors principals: Lammens, Alfred, Baehner, Monika, Kohnert, Ulrich, Niewoehner, Jens, von Proff, Leopold, Schraeml, Michael, Lammens, Katja, Hopfner, Karl-Peter
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648529/
https://ncbi.nlm.nih.gov/pubmed/23667509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062697
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