If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level. Metformin increases lifespan and prevents cancer in mice, although its effects vary, depending on mice strain and gender. Here we showed that chro...

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Detalhes bibliográficos
Main Authors: Anisimov, Vladimir N., Berstein, Lev M., Popovich, Irina G., Zabezhinski, Mark A., Egormin, Peter A., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Margarita L., Yurova, Maria N., Kovalenko, Irina G., Poroshina, Tatiana E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2011
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082009/
https://ncbi.nlm.nih.gov/pubmed/21386129
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