Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil: Is it time to move forward?

Thymidylate synthase is a target of 5-fluoruracil, a pyrimidine analog used to treat gastrointestinal and other cancers. The 5-fluorouracil metabolite, fluoro-deoxyuridine monophosphate, forms a ternary complex with thymidylate synthase and 5,10-methylene tetrahydrofolate. The purpose of this study...

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Main Authors: Showalter, Shayna L., Showalter, Timothy N., Witkiewicz, Agnes, Havens, Robert, Kennedy, Eugene P., Hucl, Tomas, Kern, Scott E., Yeo, Charles J., Brody, Jonathan R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081718/
https://ncbi.nlm.nih.gov/pubmed/18443433
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