Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies

Complete loss or deletion of the long arm of chromosome 5 is frequent in myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). The putative gene(s) deleted and responsible for the pathogenesis of these poor prognosis hematological disorders remain controversial. This study is a compre...

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Main Authors: Ye, Ying, McDevitt, Michael A., Guo, Mingzhou, Zhang, Wei, Galm, Oliver, Gore, Steven D., Karp, Judith E., Maciejewski, Jaroslaw P., Kowalski, Jeanne, Tsai, Hua-Ling, Gondek, Lukasz P., Tsai, Hsing-Chen, Wang, Xiaofei, Hooker, Craig, Smith, B. Douglas, Carraway, Hetty E., Herman, James G.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081599/
https://ncbi.nlm.nih.gov/pubmed/19826047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1153
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