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The effect of mitoxantrone as an anticancer drug on hepatocytes nuclei and chromatin: Selective release of histone proteins

OBJECTIVES: Mitoxantrone is an anticancer drug widely used in the treatment of various cancers. In the present study the effect of mitoxantrone on chromatin proteins of intact hepatocytes nuclei was investigated and compared with soluble chromatin. MATERIALS AND METHODS: UV/Vis spectroscopy, SDS pol...

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Bibliografski detalji
Glavni autori: Hajihassan, Zahra, Rabbani-Chadegani, Azra
Format: Artigo
Jezik:Inglês
Izdano: Medknow Publications 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081460/
https://ncbi.nlm.nih.gov/pubmed/21572656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0253-7613.77362
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