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The effect of mitoxantrone as an anticancer drug on hepatocytes nuclei and chromatin: Selective release of histone proteins
OBJECTIVES: Mitoxantrone is an anticancer drug widely used in the treatment of various cancers. In the present study the effect of mitoxantrone on chromatin proteins of intact hepatocytes nuclei was investigated and compared with soluble chromatin. MATERIALS AND METHODS: UV/Vis spectroscopy, SDS pol...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Medknow Publications
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081460/ https://ncbi.nlm.nih.gov/pubmed/21572656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0253-7613.77362 |
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