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Studies on the binding affinity of anticancer drug mitoxantrone to chromatin, DNA and histone proteins
Mitoxantrone is a potent antitumor drug, widely used in the treatment of various cancers. In the present study, we have investigated and compared the affinity of anticancer drug, mitoxantrone, to EDTA-soluble chromatin (SE-chromatin), DNA and histones employing UV/Vis, fluorescence, CD spectroscopy,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2660295/ https://ncbi.nlm.nih.gov/pubmed/19284573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-16-31 |
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