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Rdh10 Mutants Deficient in Limb Field Retinoic Acid Signaling Exhibit Normal Limb Patterning but Display Interdigital Webbing
Retinoic acid (RA) is purported to be required for expression of genes controlling proximodistal (Meis2) or anteroposterior (Shh) limb patterning. Embryos lacking RDH10, the primary enzyme synthesizing retinaldehyde during mouse development, survive until E14.5 with stunted forelimbs but apparently...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081420/ https://ncbi.nlm.nih.gov/pubmed/21360789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22583 |
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