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Mechanisms of retinoic acid signalling and its roles in organ and limb development

Retinoic acid (RA) signalling has a central role during vertebrate development. RA synthesized in specific locations regulates transcription by interacting with nuclear RA receptors (RARs) bound to RA response elements (RAREs) near target genes. RA was first implicated in signalling on the basis of...

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Detalhes bibliográficos
Publicado no:Nat Rev Mol Cell Biol
Main Authors: Cunningham, Thomas J., Duester, Gregg
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636111/
https://ncbi.nlm.nih.gov/pubmed/25560970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm3932
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