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Mechanisms of retinoic acid signalling and its roles in organ and limb development

Retinoic acid (RA) signalling has a central role during vertebrate development. RA synthesized in specific locations regulates transcription by interacting with nuclear RA receptors (RARs) bound to RA response elements (RAREs) near target genes. RA was first implicated in signalling on the basis of...

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Bibliographic Details
Published in:Nat Rev Mol Cell Biol
Main Authors: Cunningham, Thomas J., Duester, Gregg
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636111/
https://ncbi.nlm.nih.gov/pubmed/25560970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm3932
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