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Donepezil Plus Estradiol Treatment Enhances Learning and Delay-Dependent Memory Performance by Young Ovariectomized Rats with Partial Loss of Septal Cholinergic Neurons

Effects of estrogen therapy on cognitive performance appear to diminish with age and time following the loss of ovarian function. We hypothesize that this is due to a reduction in basal forebrain cholinergic function and that treatment with a cholinergic enhancer can reverse the effect. This study t...

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Main Authors: Gibbs, R.B., Chipman, A.M., Nelson, D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081392/
https://ncbi.nlm.nih.gov/pubmed/21295576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yhbeh.2011.01.011
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