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Aptameric inhibition of p210bcr-abl tyrosine kinase autophosphorylation by oligodeoxynucleotides of defined sequence and backbone structure.

Protein tyrosine kinases play key roles in cellular physiology. Specific inhibitors of these enzymes are important laboratory tools and may prove to be novel therapeutic agents. In this report we describe a new class of tyrosine kinase inhibitor, synthetic oligodeoxynucleotides (ODNs). An ODN is des...

詳細記述

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書誌詳細
主要な著者: Bergan, R, Connell, Y, Fahmy, B, Kyle, E, Neckers, L
フォーマット: Artigo
言語:Inglês
出版事項: 1994
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC308134/
https://ncbi.nlm.nih.gov/pubmed/8029025
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