Aptameric inhibition of p210bcr-abl tyrosine kinase autophosphorylation by oligodeoxynucleotides of defined sequence and backbone structure.

Protein tyrosine kinases play key roles in cellular physiology. Specific inhibitors of these enzymes are important laboratory tools and may prove to be novel therapeutic agents. In this report we describe a new class of tyrosine kinase inhibitor, synthetic oligodeoxynucleotides (ODNs). An ODN is des...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Bergan, R, Connell, Y, Fahmy, B, Kyle, E, Neckers, L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1994
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC308134/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8029025/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.11.2150
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