Progression to AIDS in South Africa Is Associated with both Reverting and Compensatory Viral Mutations

We lack the understanding of why HIV-infected individuals in South Africa progress to AIDS. We hypothesised that in end-stage disease there is a shifting dynamic between T cell imposed immunity and viral immune escape, which, through both compensatory and reverting viral mutations, results in increa...

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Main Authors: Huang, Kuan-Hsiang Gary, Goedhals, Dominique, Carlson, Jonathan M., Brockman, Mark A., Mishra, Swati, Brumme, Zabrina L., Hickling, Stephen, Tang, Christopher S. W., Miura, Toshiyuki, Seebregts, Chris, Heckerman, David, Ndung'u, Thumbi, Walker, Bruce, Klenerman, Paul, Steyn, Dewald, Goulder, Philip, Phillips, Rodney, van Vuuren, Cloete, Frater, John
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081339/
https://ncbi.nlm.nih.gov/pubmed/21544209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019018
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