Direct detection of nucleic acid hybridization on the surface of a charge coupled device.

A method is described for the detection of DNA hybrids formed on a solid support, based upon the pairing of oligonucleotide chemistry and the technologies of electronic microdevice design. Surface matrices have been created in which oligonucleotide probes are covalently linked to a thin SiO2 film. 3...

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Bibliographic Details
Main Authors: Lamture, J B, Beattie, K L, Burke, B E, Eggers, M D, Ehrlich, D J, Fowler, R, Hollis, M A, Kosicki, B B, Reich, R K, Smith, S R
Format: Artigo
Language:Inglês
Published: 1994
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC308130/
https://ncbi.nlm.nih.gov/pubmed/8029021
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