Matriptase initiates epidermal prokallikrein activation and disease onset in a mouse model of Netherton syndrome

Deficiency in the serine protease inhibitor LEKTI is the etiological origin of Netherton syndrome. The principal morbidities of the disease are stratum corneum detachment and chronic inflammation. We show that the membrane protease, matriptase, initiates Netherton syndrome in a LEKTI-deficient mouse...

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Auteurs principaux: Sales, Katiuchia Uzzun, Masedunskas, Andrius, Bey, Alexandra L., Rasmussen, Amber, Weigert, Roberto, List, Karin, Szabo, Roman, Overbeek, Paul A., Bugge, Thomas H.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081165/
https://ncbi.nlm.nih.gov/pubmed/20657595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.629
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