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Matriptase initiates epidermal prokallikrein activation and disease onset in a mouse model of Netherton syndrome
Deficiency in the serine protease inhibitor LEKTI is the etiological origin of Netherton syndrome. The principal morbidities of the disease are stratum corneum detachment and chronic inflammation. We show that the membrane protease, matriptase, initiates Netherton syndrome in a LEKTI-deficient mouse...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081165/ https://ncbi.nlm.nih.gov/pubmed/20657595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.629 |
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