Matriptase initiates epidermal prokallikrein activation and disease onset in a mouse model of Netherton syndrome

Deficiency in the serine protease inhibitor LEKTI is the etiological origin of Netherton syndrome. The principal morbidities of the disease are stratum corneum detachment and chronic inflammation. We show that the membrane protease, matriptase, initiates Netherton syndrome in a LEKTI-deficient mouse...

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Autores principales: Sales, Katiuchia Uzzun, Masedunskas, Andrius, Bey, Alexandra L., Rasmussen, Amber, Weigert, Roberto, List, Karin, Szabo, Roman, Overbeek, Paul A., Bugge, Thomas H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081165/
https://ncbi.nlm.nih.gov/pubmed/20657595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.629
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