Skp2 Overexpression Is Associated with Loss of BRCA2 Protein in Human Prostate Cancer

BRCA2 (breast cancer 2, early onset) is a tumor suppressor gene that confers increased susceptibility for prostate cancer (PCa). Previous in vitro experiments demonstrated that Skp2, an E3 ubiquitin ligase aberrantly overexpressed in PCa, is involved in the proteolytic degradation of BRCA2 in PCa ce...

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Bibliografiske detaljer
Main Authors: Arbini, Arnaldo A., Greco, Margherita, Yao, Jorge L., Bourne, Patricia, Marra, Ersilia, Hsieh, Jer-Tsong, di Sant'Agnese, Paul A., Moro, Loredana
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2011
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081144/
https://ncbi.nlm.nih.gov/pubmed/21514447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.050
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