Skp2 Overexpression Is Associated with Loss of BRCA2 Protein in Human Prostate Cancer

BRCA2 (breast cancer 2, early onset) is a tumor suppressor gene that confers increased susceptibility for prostate cancer (PCa). Previous in vitro experiments demonstrated that Skp2, an E3 ubiquitin ligase aberrantly overexpressed in PCa, is involved in the proteolytic degradation of BRCA2 in PCa ce...

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Autores principales: Arbini, Arnaldo A., Greco, Margherita, Yao, Jorge L., Bourne, Patricia, Marra, Ersilia, Hsieh, Jer-Tsong, di Sant'Agnese, Paul A., Moro, Loredana
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2011
Materias:
Regular Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3081144/
https://ncbi.nlm.nih.gov/pubmed/21514447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.01.050
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