Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study

AIMS: Pharmacokinetic studies suggest that trimethoprim (TMP) can inhibit the hepatic metabolism of phenytoin, but the clinical relevance of this is uncertain. We studied the risk of phenytoin toxicity following the prescription of trimethoprim/sulfamethoxazole (TMP/SMX), a commonly used antibiotic,...

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Bibliografske podrobnosti
Main Authors: Antoniou, Tony, Gomes, Tara, Mamdani, Muhammad M, Juurlink, David N
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2011
Teme:
Drug Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080642/
https://ncbi.nlm.nih.gov/pubmed/21395647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03866.x
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