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Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study

AIMS: Pharmacokinetic studies suggest that trimethoprim (TMP) can inhibit the hepatic metabolism of phenytoin, but the clinical relevance of this is uncertain. We studied the risk of phenytoin toxicity following the prescription of trimethoprim/sulfamethoxazole (TMP/SMX), a commonly used antibiotic,...

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Bibliografische gegevens
Hoofdauteurs: Antoniou, Tony, Gomes, Tara, Mamdani, Muhammad M, Juurlink, David N
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Science Inc 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080642/
https://ncbi.nlm.nih.gov/pubmed/21395647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03866.x
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