In silico prediction of efavirenz and rifampicin drug–drug interaction considering weight and CYP2B6 phenotype

AIMS: This study aimed to test whether a pharmacokinetic simulation model could extrapolate nonclinical drug data to predict human efavirenz exposure after single and continuous dosing as well as the effects of concomitant rifampicin and further to evaluate the weight-based dosage recommendations us...

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Bibliographic Details
Main Authors: Rekić, Dinko, Röshammar, Daniel, Mukonzo, Jackson, Ashton, Michael
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2011
Subjects:
Drug Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080641/
https://ncbi.nlm.nih.gov/pubmed/21395646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03883.x
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