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Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects

AIM: The primary objective was to evaluate the pharmacokinetics of a single dose of neratinib, a potent, low-molecular-weight, orally administered, irreversible pan-ErbB (ErbB-1, -2, -4) receptor tyrosine kinase inhibitor, during co-administration with ketoconazole, a potent CYP3A4 inhibitor. METHOD...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Abbas, Richat, Hug, Bruce A, Leister, Cathie, Burns, Jaime, Sonnichsen, Daryl
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080639/
https://ncbi.nlm.nih.gov/pubmed/21395644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03845.x
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