Caricamento...

Isofagomine In Vivo Effects in a Neuronopathic Gaucher Disease Mouse

The pharmacological chaperone, isofagomine (IFG), enhances acid β-glucosidase (GCase) function by altering folding, trafficking, and activity in wild-type and Gaucher disease fibroblasts. The in vivo effects of IFG on GCase activity, its substrate levels, and phenotype were evaluated using a neurono...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Sun, Ying, Ran, Huimin, Liou, Benjamin, Quinn, Brian, Zamzow, Matt, Zhang, Wujuan, Bielawski, Jacek, Kitatani, Kazuyuki, Setchell, Kenneth D. R., Hannun, Yusuf A., Grabowski, Gregory A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080394/
https://ncbi.nlm.nih.gov/pubmed/21533102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019037
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !