Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

Suppression of autophagy is always accompanied by marked accumulation of p62, a selective autophagy substrate. Because p62 interacts with the Nrf2-binding site on Keap1, which is a Cullin 3–based ubiquitin ligase adapter protein, autophagy deficiency causes competitive inhibition of the Nrf2–Keap1 i...

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Bibliographic Details
Main Authors: Inami, Yoshihiro, Waguri, Satoshi, Sakamoto, Ayako, Kouno, Tsuguka, Nakada, Kazuto, Hino, Okio, Watanabe, Sumio, Ando, Jin, Iwadate, Manabu, Yamamoto, Masayuki, Lee, Myung-Shik, Tanaka, Keiji, Komatsu, Masaaki
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2011
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080263/
https://ncbi.nlm.nih.gov/pubmed/21482715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201102031
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