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Activation of Unfolded Protein Response in Transgenic Mouse Lenses

PURPOSE. Overloading of unfolded or misfolded proteins in the endoplasmic reticulum (ER) can cause ER stress and activate the unfolded protein response (UPR) in the cell. The authors tested whether transgene overexpression in the mouse lens would activate the UPR. METHODS. Transgenic mice expressing...

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Autors principals: Reneker, Lixing W., Chen, Huiyi, Overbeek, Paul A.
Format: Artigo
Idioma:Inglês
Publicat: Association for Research in Vision and Ophthalmology, Inc. 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080171/
https://ncbi.nlm.nih.gov/pubmed/21310900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-5650
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