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Activation of Unfolded Protein Response in Transgenic Mouse Lenses
PURPOSE. Overloading of unfolded or misfolded proteins in the endoplasmic reticulum (ER) can cause ER stress and activate the unfolded protein response (UPR) in the cell. The authors tested whether transgene overexpression in the mouse lens would activate the UPR. METHODS. Transgenic mice expressing...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Association for Research in Vision and Ophthalmology, Inc.
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3080171/ https://ncbi.nlm.nih.gov/pubmed/21310900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-5650 |
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