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Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens

PURPOSE: Insulin and insulin-like growth factors (IGFs) are putative regulators of cell proliferation and differentiation during lens development. Transgenic mice that overexpress IGF-1 in the lens have been previously described. To further understand the ocular functions of this growth factor famil...

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Detalhes bibliográficos
Main Authors: Xie, Leike, Chen, Huiyi, Overbeek, Paul A., Reneker, Lixing W.
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Vision 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642934/
https://ncbi.nlm.nih.gov/pubmed/17417601
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