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Optimizing Non-natural Protein Function with Directed Evolution

Developing technologies such as unnatural amino acid mutagenesis, non-natural cofactor engineering, and computational design are generating proteins with novel functions; these proteins, however, often do not reach performance targets and would benefit from further optimization. Evolutionary methods...

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Detalhes bibliográficos
Main Authors: Brustad, Eric M, Arnold, Frances H
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080047/
https://ncbi.nlm.nih.gov/pubmed/21185770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2010.11.020
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