Antibodies generated from human immunoglobulin miniloci in transgenic mice.

One approach to the production of human monoclonal antibodies focusses on the creation of transgenic mice bearing human immunoglobulin gene miniloci. Whilst such loci undergo lymphoid-specific gene rearrangement, only a small proportion of mouse B cells express the human immunoglobulin chains; the m...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Wagner, S D, Williams, G T, Larson, T, Neuberger, M S, Kitamura, D, Rajewsky, K, Xian, J, Brüggemann, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1994
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307995/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8190629/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.8.1389
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