Continuous Localized Monitoring of Plasmin Activity Identifies Differential and Regional Effects of the Serine Protease Inhibitor Aprotinin: Relevance to Antifibrinolytic Therapy

BACKGROUND: Antifibrinolytic therapy, such as the use of the serine protease inhibitor aprotinin, was a mainstay for hemostasis following cardiac surgery. However, aprotinin was empirically dosed, and while the pharmacological target was the inhibition of plasmin activity (PLact) this was never moni...

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Main Authors: Reust, Daryl L., Dixon, Jennifer A., McKinney, Richard A., Patel, Risha K., Rivers, William T., Mukherjee, Rupak, Stroud, Robert E., Madden, Karen, Groves, Kevin, Rajopadhye, Milind, Reeves, Scott T., Abernathy, James H., Spinale, Francis G.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079882/
https://ncbi.nlm.nih.gov/pubmed/21502925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0b013e31820b7df1
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