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DNA sequence specificity of mitoxantrone.
An in vitro transcription assay was used to determine the sequence specificity of binding of mitoxantrone to a 497 bp fragment of DNA containing the lac UV5 promoter. Transcriptional blockages of the E. coli RNA polymerase were observed dominantly prior to 5'-CpA sequences (64% occurrence), and...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1994
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC307987/ https://ncbi.nlm.nih.gov/pubmed/8190623 |
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