γ-Glutamylcysteine Ameliorates Oxidative Injury in Neurons and Astrocytes In Vitro and Increases Brain Glutathione In Vivo

γ-Glutamylcysteine (γ-GC) is an intermediate molecule of the glutathione (GSH) synthesis pathway. In the present study, we tested the hypothesis that γ-GC pretreatment in cultured astrocytes and neurons protects against hydrogen peroxide (H(2)O(2))-induced oxidative injury. We demonstrate that pretr...

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Main Authors: Le, Truc M., Jiang, Haiyan, Cunningham, Gary R., Magarik, Jordan A., Barge, William S., Cato, Marilyn C., Farina, Marcelo, Rocha, Joao B. T., Milatovic, Dejan, Lee, Eunsook, Aschner, Michael, Summar, Marshall L.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079792/
https://ncbi.nlm.nih.gov/pubmed/21159318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2010.11.008
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