The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ(40) Oligomers in Human Astrocytes

Glutathione (GSH) is one of the most abundant thiol antioxidants in cells. Many chronic and age-related diseases are associated with a decline in cellular GSH levels or impairment in the catalytic activity of the GSH biosynthetic enzyme glutamate cysteine ligase (GCL). γ-glutamylcysteine (GGC), a pr...

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Vydáno v:Front Aging Neurosci
Hlavní autoři: Braidy, Nady, Zarka, Martin, Jugder, Bat-Erdene, Welch, Jeffrey, Jayasena, Tharusha, Chan, Daniel K. Y., Sachdev, Perminder, Bridge, Wallace
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694290/
https://ncbi.nlm.nih.gov/pubmed/31440155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2019.00177
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