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A Panel of Artificial APCs Expressing Prevalent HLA Alleles Permits Generation of Cytotoxic T Cells Specific for Both Dominant and Subdominant Viral Epitopes for Adoptive Therapy

Adoptive transfer of virus-specific T cells can treat infections complicating allogeneic hematopoietic cell transplants. However, autologous antigen-presenting cells (APCs) are often limited in supply. Here, we describe a panel of artificial APCs (AAPCs) consisting of murine 3T3 cells transduced to...

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Detalhes bibliográficos
Main Authors: Hasan, Aisha N., Kollen, Wouter J., Trivedi, Deepa, Selvakumar, Annamalai, Dupont, Bo, Sadelain, Michel, O'Reilly, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079474/
https://ncbi.nlm.nih.gov/pubmed/19635907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0804178
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