Autophagy proteins regulate innate immune response by inhibiting NALP3 inflammasome-mediated mitochondrial DNA release

Autophagy, a cellular process for organelle and protein turnover, regulates innate immune responses. We demonstrate that depletion of autophagic proteins microtubule associated protein-1 light chain 3B (LC3B) and Beclin 1 enhances caspase-1 activation and secretion of interleukin-1β and interleukin-...

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Autors principals: Nakahira, Kiichi, Haspel, Jeffrey Adam, Rathinam, Vijay AK, Lee, Seon-Jin, Dolinay, Tamas, Lam, Hilaire C, Englert, Joshua A, Rabinovitch, Marlene, Cernadas, Manuela, Kim, Hong Pyo, Fitzgerald, Katherine A, Ryter, Stefan W, Choi, Augustine MK
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079381/
https://ncbi.nlm.nih.gov/pubmed/21151103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1980
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