Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

Endoplasmic reticulum (ER) stress has been implicated in the pathophysiology of human type 2 diabetes (T2DM). Although SIRT1 has a therapeutic effect on metabolic deterioration in T2DM, the precise mechanisms by which SIRT1 improves insulin resistance remain unclear. Here, we demonstrate that adenov...

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Detalhes bibliográficos
Main Authors: Li, Yu, Xu, Shanqin, Giles, Amber, Nakamura, Kazuto, Lee, Jong Woo, Hou, Xiuyun, Donmez, Gizem, Li, Ji, Luo, Zhijun, Walsh, Kenneth, Guarente, Leonard, Zang, Mengwei
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2011
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079300/
https://ncbi.nlm.nih.gov/pubmed/21321189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-173492
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