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Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes
Molecular dynamics simulation identified three highly conserved rRNA bases in the large subunit of the ribosome that form a three-dimensional (3D) “gate” that induces pausing of the aa-tRNA acceptor stem during accommodation into the A-site. A nearby fourth base contacting the “tryptophan finger” of...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3078735/ https://ncbi.nlm.nih.gov/pubmed/21441349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2593211 |
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