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Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes
Molecular dynamics simulation identified three highly conserved rRNA bases in the large subunit of the ribosome that form a three-dimensional (3D) “gate” that induces pausing of the aa-tRNA acceptor stem during accommodation into the A-site. A nearby fourth base contacting the “tryptophan finger” of...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2011
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3078735/ https://ncbi.nlm.nih.gov/pubmed/21441349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2593211 |
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