Proneurotrophin-3 may induce Sortilin dependent death in inner ear neurons

The precursor of the neurotrophin NGF (proNGF) serves physiological functions distinct from its mature counterpart as it induces neuronal apoptosis through activation of a p75 neurotrophin receptor (p75(NTR)) and Sortilin death-signalling complex. The neurotrophins BDNF and NT3 provide essential tro...

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Detalhes bibliográficos
Main Authors: Tauris, Jacob, Gustafsen, Camilla, Christensen, Erik Ilsø, Jansen, Pernille, Nykjaer, Anders, Nyengaard, Jens R., Teng, Kenneth K., Schwarz, Elisabeth, Ovesen, Therese, Madsen, Peder, Petersen, Claus Munck
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078644/
https://ncbi.nlm.nih.gov/pubmed/21261755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2010.07556.x
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