Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2

BACKGROUND: Single-nucleotide polymorphisms (SNPs) in genes involved in DNA repair are good candidates to be tested as phenotypic modifiers for carriers of mutations in the high-risk susceptibility genes BRCA1 and BRCA2. The base excision repair (BER) pathway could be particularly interesting given...

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Autori principali: Osorio, A, Milne, R L, Alonso, R, Pita, G, Peterlongo, P, Teulé, A, Nathanson, K L, Domchek, S M, Rebbeck, T, Lasa, A, Konstantopoulou, I, Hogervorst, F B, Verhoef, S, van Dooren, M F, Jager, A, Ausems, M G E M, Aalfs, C M, van Asperen, C J, Vreeswijk, M, Waisfisz, Q, Van Roozendaal, C E, Ligtenberg, M J, Easton, D F, Peock, S, Cook, M, Oliver, C T, Frost, D, Curzon, B, Evans, D G, Lalloo, F, Eeles, R, Izatt, L, Davidson, R, Adlard, J, Eccles, D, Ong, K-r, Douglas, F, Downing, S, Brewer, C, Walker, L, Nevanlinna, H, Aittomäki, K, Couch, F J, Fredericksen, Z, Lindor, N M, Godwin, A, Isaacs, C, Caligo, M A, Loman, N, Jernström, H, Barbany-Bustinza, G, Liljegren, A, Ehrencrona, H, Stenmark-Askmalm, M, Feliubadaló, L, Manoukian, S, Peissel, B, Zaffaroni, D, Bonanni, B, Fortuzzi, S, Johannsson, O T, Chenevix-Trench, G, Chen, X-C, Beesley, J, Spurdle, A B, Sinilnikova, O M, Healey, S, McGuffog, L, Antoniou, A C, Brunet, J, Radice, P, Benítez, J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
Soggetti:
Genetics and Genomics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078599/
https://ncbi.nlm.nih.gov/pubmed/21427728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.91
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