Phenocopies in BRCA1 and BRCA2 families: evidence for modifier genes and implications for screening

BACKGROUND: The identification of BRCA1 and BRCA2 mutations in familial breast cancer kindreds allows genetic testing of at‐risk relatives. Those who test negative are usually reassured and additional breast cancer surveillance is discontinued. However, we postulated that in high‐risk families, such...

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Autores principales: Smith, A, Moran, A, Boyd, M C, Bulman, M, Shenton, A, Smith, L, Iddenden, R, Woodward, E R, Lalloo, F, Maher, E R, Evans, D G R
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Group 2007
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597903/
https://ncbi.nlm.nih.gov/pubmed/17079251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2006.043091
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