Phenocopies in BRCA1 and BRCA2 families: evidence for modifier genes and implications for screening

BACKGROUND: The identification of BRCA1 and BRCA2 mutations in familial breast cancer kindreds allows genetic testing of at‐risk relatives. Those who test negative are usually reassured and additional breast cancer surveillance is discontinued. However, we postulated that in high‐risk families, such...

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Autori principali: Smith, A, Moran, A, Boyd, M C, Bulman, M, Shenton, A, Smith, L, Iddenden, R, Woodward, E R, Lalloo, F, Maher, E R, Evans, D G R
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2007
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597903/
https://ncbi.nlm.nih.gov/pubmed/17079251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2006.043091
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