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On the rapid deprotection of synthetic oligonucleotides and analogs.

The efficiency of oligodeoxynucleotide deprotection is greatly enhanced using a combination of: (a) ethanolamine, and especially a mixture of hydrazine, ethanolamine and methanol, in place of the usual aqueous ammonia; (b) tert-butylphenoxyacetyl amino protecting groups, and (c) oxalyl link between...

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Publicat a:Nucleic Acids Res
Autors principals: Polushin, N N, Morocho, A M, Chen, B C, Cohen, J S
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 1994
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307855/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8127712/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.4.639
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